Oncology

CT01681’s ability to safely modulate the cytokine response makes it an ideal solution to address CAR T-Cell Therapy-related CRS in oncology

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Stanley Marks, MD
Chairman, UPMC Hillman Cancer Center

Dr. Marks on CRS in
CAR T-Cell Patients

“As someone who has dedicated my life to cancer treatment, patient advocacy and innovation, I’m highly motivated to solve the CRS problem associated with CAR T-Cell Therapy. CTO1681 could not only treat, but perhaps prevent, CRS altogether. Reducing this life-threatening side effect will allow us to treat and cure more patients with CAR T-Cell Therapy.”

 

Addressing Unmet Needs in Oncology

500%
increase in CAR T-Cell Therapy eligible patients by 2026
70%
of CAR T-Cell Therapy patients are at risk of CRS as a side effect of their treatment
25+
cytokines have been shown to be reduced in studies with CTO1681

CTO1681 Treats CRS Triggered by
CAR T-Cell Therapy and Bispecific Antibody Therapy

CTO1681 reduces the cytokines generated during Cytokine Release Syndrome CAR T-Cell Therapy while enabling the body to maintain appropriate cytokine levels. Reducing the rates and severity of toxicity allows for the treatment of more patients, treatment in the outpatient setting, and the decrease of treatment-related morbidity.

In addition to CAR T-Cell Therapy, Bispecific Antibody Therapies are an emerging therapeutic area in immune oncology that has a significant incidence of CRS. CTO1681 reduces cytokines generated during CRS induced by bispecific antibodies without causing systemic off-target effects or increasing the risk of neurotoxicity like current CRS treatments.

Oncology Development Timeline

CTO1681’s ability to safely modulate the cytokine response makes it a promising candidate to mitigate CRS in CAR T-Cell Therapy. Because CTO1681 reduces, but does not eliminate the presence of cytokines within the immune system, it has the potential to be used to not only treat, but also prevent CRS

 

Using CTO1681 in Conjunction with
CAR T-Cell Therapy

CTO1681’s ability to modulate the cytokine response makes it a promising candidate to mitigate a common side effect of CAR T-cell therapy in oncology.

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